2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid GSK2636771
GSK2636771
CAS: 1372540-25-4
Molecular Formula: C22H22F3N3O3
2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid GSK2636771 - Names and Identifiers
2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid GSK2636771 - Physico-chemical Properties
| Molecular Formula | C22H22F3N3O3 |
| Molar Mass | 433.42 |
| Density | 1.38 |
| Melting Point | >225°C (dec.) |
| Boling Point | 641.3±55.0 °C(Predicted) |
| Solubility | DMSO 28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | Solid |
| Color | Pale Yellow |
| pKa | -2.70±0.30(Predicted) |
| Storage Condition | -20°C Freezer |
| In vitro study | GSK-2636771 has selective inhibitory activity against PTEN-deficient cell lines (human prostate cancer PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. |
| In vivo study | These xenograft models were treated GSK-2636771 to reduce the level of the phosphorylated protein kinase Akt(Ser473). Treatment of mice with GSK-2636771(100 mg/kg) did not increase glucose/insulin levels. |
2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid GSK2636771 - Introduction
GSK2636771 is an orally biopotent PI3Kβ selective inhibitor sensitive to PTEN deletion cell lines.
Last Update：2022-10-16 17:41:27
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CAS: 1372540-25-4
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CAS: 1372540-25-4
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View History
2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid GSK2636771
4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
Loratadine Impurity 72
3-Penten-2-one, (3E)-
3,6,9-Trioxadecanoic acid (TODS)
ene)Bis(2-MethyL
3-Azabicyclo[3.1.0]hexane-6-carboxylic acid, 2,4-dioxo-3-[3-(trifluoromethyl)phenyl]-, ethyl ester
2-[(2-chloro-4-nitrophenyl)thio]ethanohydrazide
2-Azaspiro[3.3]heptane-1-carboxylic acid hydrochloride
4-bicyclo[2.2.1]hept-2-yl-3-methyl-3-buten-2-one
4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
Loratadine Impurity 72
3-Penten-2-one, (3E)-
3,6,9-Trioxadecanoic acid (TODS)
ene)Bis(2-MethyL
3-Azabicyclo[3.1.0]hexane-6-carboxylic acid, 2,4-dioxo-3-[3-(trifluoromethyl)phenyl]-, ethyl ester
2-[(2-chloro-4-nitrophenyl)thio]ethanohydrazide
2-Azaspiro[3.3]heptane-1-carboxylic acid hydrochloride
4-bicyclo[2.2.1]hept-2-yl-3-methyl-3-buten-2-one